الاخوة الافاضل الاطباء
what is the differance between oxytetracycline and chlorotetracycline
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اخي الكريم الاوكسي هو مضاد حيوي ذو تأثير 50%على الجراثيم التنفسية و50% على الجراثيم المعويو والجهازية وهو موجود بعدة اشكال ويعطى لكل الحيوانات ام كلور تتراسكلين فهو ذو تأثير 85-90% على الجراثيم المعوية وهو يستعمل للدواجن فقط وذلك في سوريا

Oxytetracycline and tetracycline share nearly identical spectrums of activity and patterns of crossresistance
and a tetracycline susceptibility disk is usually used for in vitro testing for
oxytetracycline susceptibility.

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Both oxytetracycline and tetracycline are readily absorbed after oral administration
to fasting animals. Bioavailabilities are approximately 60-80%. The presence of food or
dairy products can significantly reduce the amount of tetracycline absorbed, with reductions of 50%
or more possible. After IM administration, tetracycline is erratically and poorly absorbed with
serum levels usually lower than those attainable with oral therapy.
Tetracyclines as a class, are widely distributed to heart, kidney, lungs, muscle, pleural fluid,
bronchial secretions, sputum, bile, saliva, urine, synovial fluid, ascitic fluid, and aqueous and vitreous
humor. Only small quantities of tetracycline and oxytetracycline are distributed to the CSF, and
therapeutic levels may not be achievable. While all tetracyclines distribute to the prostate and eye,
doxycycline or minocycline penetrate better into these and most other tissues. Tetracyclines cross
the placenta, enter fetal circulation and are distributed into milk. The volume of distribution of
tetracycline is approximately 1.2 - 1.3 L/kg in small animals. The amount of plasma protein binding
is about 20 - 67% for tetracycline.
Both oxytetracycline and tetracycline are eliminated unchanged primarily via glomerular filtration.
Patients with impaired renal function can have prolonged elimination half-lives and may accumulate
the drug with repeated dosing. These drugs apparently are not metabolized, but are excreted into the
GI tract via both biliary and nonbiliary routes and may become inactive after chelation with fecal
materials. The elimination half-life of tetracycline is approximately 5-6 hours in dogs and cats

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